Although not receiving much attention, the manufacturing and use of biomaterials has caused a significant environmental impact. Whether from the use and discard of polymeric catheters to the plastics used during in vitro testing, it is clear that biomaterial use, synthesis, and research is responsible for global warming. The same can also be said for metals, where many of today’s metallic biomaterials (titanium, stainless steel, etc.) leave a large environmental footprint. This presentation will discuss how nanotechnology is being used to reduce the environmental impact of today’s biomaterials. Specifically, it will introduce how cells can be used to make nanoparticles without resorting to the use of toxic chemicals used during conventional nanoparticle synthesis. It will also discuss how natural materials are being used as next generation improved biomaterials. The invited talk will also cover how such “green nanomedicine” is not only reducing the impact on the environment but is also creating more effective biomaterials to promote tissue growth, reduce infection, and inhibit inflammation.