Title : Dopamine Sensor based on Coreshell Polyparaphenylene Diamine/ Titanium Dioxide/ Multiwalled Carbon Nanotube Nanocomposite
Abstract:
Polymer nanocomposites based on conducting electroactive polymers with nanoparticle fillers have acquired a lot of interest in recent years due to their highly desired multifunctional properties. In the diagnosis of many mental illnesses, an accurate and sensitive assessment of dopamine as a biomarker for ailments like Parkinsons, is critical. As dopamine coexists with other high-concentration biomolecules in biological samples, determining it remains difficult. In this regard, a novel nanocomposite has been synthesized and analysed. P-phenylenediamine was polymerized, and composites were prepared by adding TiO2 and multiwalled carbon nanotube into the polymer with magnetic stirring. Analytical techniques such as UV-Vis, FT-IR, and FE-SEM were used to characterize these nanocomposites. For in vivo detection of dopamine, the novel electrochemical biosensor based on poly paraphenylenediamine and titanium dioxide decorated multiwalled carbon nanotubes was coated on GCE, and the constructed sensor was found to have sensitivity with a linear range of 4.76×10-6 – 3.81×10-11M and a limit of detection as low as 9.45×10-12M.
Keywords: Nano composites, para phenylenediamine, titanium dioxide, Multiwalled cabon nanotube. Dopamine.
