Title : Evaluation of antidiabetic activity of aqueous extract of bark of pterocarpus marsupium silver nanoparticles against streptozotocin and nicotinamide induced type 2 diabetes in rats
Diabetes Mellitus is fast gaining the status of a potential epidemic in India with more than 62 million diabetic individuals currently diagnosed with the disease.It is predicted that by 2030 diabetes mellitus may afflict up to 79.4 million individuals in India, while China (42.3 million) and the United States (30.3 million) will also see significant increases in those affected by the disease. Most plants contain carotenoids, flavonoids, terpenoids, alkaloids, glycosides and can often have anti-diabetic effects.The main purpose of this research work was to formulate silver nanoparticles with Pterocarpus marsupium Roxb. and evaluate against streptozotocin and nicotinamide induced type 2 diabetes in Wistar rats. This research work was pursued using green chemistry since it is an eco-friendly & environmentally accepted procedure. Pterocarpus marsupium silver nanoparticles are subjected to in vitro and in vivo anti-diabetic study to confirm anti-diabetic activity .The results suggested that Pterocarpus marsupium silver nanoparticle has more favorable reduction in lipid level in STZ and nicotinamide - induced diabetic rats, compared with glibenclamide as well as regeneration of ß-cells of pancreas.In conclusion it may be stated that, there occurs a significant (P<0.01) decrease in the hyperglycemic state after the administration of Pterocarpus marsupium silver nanoparticle which reduce the severity of oxidative and acuity of hyperglycemia, a process that closely linked to glucose oxidation and formation of free radicals.