Title : Synthesis, controlled release and kinetic studies of Polyacrylic acid-Polyethylene oxide/beta-Cyclodextrin nano-interpolymer complex with naproxen
The aim of this work is synthesis of a nano-interpolymer complex based on polyacrylic acid-polyethylene oxide (PAA-PEO) and β-cyclodextrin as a nanocarrier biodegradable drug delivery system. Host-guest method was used to make the nano-interpolymer complex in which beta cyclodextrin (β-CD) was applied as a suitable host. The nano-interpolymer complex was characterized by Fourier transform infrared (FTIR), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Hydrogen bonding formation between two polymers was proved by infrared spectroscopy method. The particle size in range of 12 nanometers was estimated by TEM. In the next step Naproxen (Nap) was loaded on the PAA-PEO/β-CD three component nano-interpolymer complex Then, release of Naproxen was investigated at 37 oC (human body temperature) and pH of 2.1 (gastric pH) and 7.4 (intestine pH) with UV spectrophotometer. Optimization of the PAA/PEO/β CD were investigated and by changing the amount of β-CD. Kinetic studies were also performed by using different kinetic models to investigate the Naproxen release rate.
Audience Take Away:
- Host-guest complexes are of great technological importance and have been extensively studied.
- Cyclodextrins (CD) are naturally occurring water-soluble toroidally shaped polysaccharides with a highly hydrophobic central cavity that have the ability to form inclusion complexes with a variety of organic and inorganic substrates.
- The audience will learn the synthesis method of a new nano interpolymer complex and the identification methods of the nano system and its specific applications, including the drug release system, will be reviewed. This nano-sized system can be used as a biocompatible carrier and analyzed in the scientific topics of teaching chemistry and pharmacy.