The pandemic of new coronavirus illness (COVID-19) is an unparalleled public health threat. According to studies, SARS-CoV-2 is transmitted mostly through contaminated droplets exhaled by sick patients, such as through coughing or sneezing. Individuals can be infected either directly or indirectly by fomites. Direct contact transmission occurs when infected people come into touch with saliva, respiratory secretions, or droplets that are expelled through coughing, sneezing, or speaking. Indirect contact transmission occurs when a susceptible host comes into contact with a contaminated object or surface (fomite transmission). The use of Nanoparticles in medicine has recently been hailed as ground-breaking, as it enables for accurate diagnosis and treatment of multiple diseases at once. Because of its small size, low toxicity, electrical charge, and chemical plasticity, a generic medicine can overcome a variety of barriers encountered during administration. SARS-CoV-2 entry and life cycle can be targeted with NP treatment. Several companies are continuously turning away from traditional SARS-CoV-2 treatment and preventive efforts in favor of employing nanotechnology to create and test various types of vaccines and therapies. Alternatives to this shift in the research and development paradigm could include nanotechnology and nanomedicine.